Product IntroductionBioactivity英文名:
AAA描述: AAA is an antagonist of G protein-coupled receptor 75 (GPR75).1It increases basal GPR75 protein levels and inhibits 20-HETE-induced reductions in GPR75 protein levels in PC3 cells. AAA (5 and 10 μM) also reduces 20-HETE-induced phosphorylation of EGFR, NF-κB, and Akt in, and cell migration of, PC3 cells.
体内活性: In vivo, AAA (10 mg/kg per day) reduces systolic blood pressure, albuminuria, renal angiotensin II levels, and cardiac hypertrophy in a Cyp1a1-Ren-2 transgenic rat model of malignant hypertension when administered prior to induction or after establishment of hypertension.2
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: PBS (pH 7.2) : 1 mg/mL
DMSO : Slightly soluble
关键字:
AAA