Concanamycin B T36116
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Product IntroductionBioactivity英文名: Concanamycin B描述: Concanamycin B is a macrolide antibiotic that selectively inhibits
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Product Introduction
Bioactivity
英文名: Concanamycin B
描述: Concanamycin B is a macrolide antibiotic that selectively inhibits vacuolar type H+-ATPases, also known as V-ATPases (IC50 = 5 nM). In this way, it blocks the acidification of vacuolar organelles as well as early to late endosomal transport. Concanamycin B interferes with bone resorption and maturation of CD8 T lymphocytes. It also prevents processing of major histocompatibility complex (MHC) class II precursors in human B cells, inhibiting the expression of MHC class II molecules on the cell surface.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : Soluble
DMF : Soluble
Ethanol : Soluble
Methanol : Soluble
关键字: Concanamycin B
Bioactivity
英文名: Concanamycin B
描述: Concanamycin B is a macrolide antibiotic that selectively inhibits vacuolar type H+-ATPases, also known as V-ATPases (IC50 = 5 nM). In this way, it blocks the acidification of vacuolar organelles as well as early to late endosomal transport. Concanamycin B interferes with bone resorption and maturation of CD8 T lymphocytes. It also prevents processing of major histocompatibility complex (MHC) class II precursors in human B cells, inhibiting the expression of MHC class II molecules on the cell surface.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : Soluble
DMF : Soluble
Ethanol : Soluble
Methanol : Soluble
关键字: Concanamycin B
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