CAY10561 T36672
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Product IntroductionBioactivity英文名: CAY10561描述: The extracellular signal-regulated kinase (ERK) signal transduction pathw
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Product Introduction
Bioactivity
英文名: CAY10561
描述: The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes. These processes include cell survival, proliferation, motility, and differentiation and are constitutively activated in cancers involving lung, colon, pancreas, kidney, and ovary. CAY10561 is a potent, ATP-competitive inhibitor of ERK2 (Ki = 2 nM). This compound is highly selective for ERK2 compared to other kinases such as PKA (Ki = 0.39 μM) and JNK3 (Ki = 4 μM). CAY10561 inhibits proliferation of COLO 205 cells with an IC50 value of 0.54 μM.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: Ethanol : 5 mg/mL
Ethanol:PBS (pH 7.2) (1:1) : 0.5 mg/mL
DMF : 2.5 mg/mL
DMSO : 1.5 mg/mL
关键字: CAY10561 | CAY 10561 | CAY-10561
Bioactivity
英文名: CAY10561
描述: The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes. These processes include cell survival, proliferation, motility, and differentiation and are constitutively activated in cancers involving lung, colon, pancreas, kidney, and ovary. CAY10561 is a potent, ATP-competitive inhibitor of ERK2 (Ki = 2 nM). This compound is highly selective for ERK2 compared to other kinases such as PKA (Ki = 0.39 μM) and JNK3 (Ki = 4 μM). CAY10561 inhibits proliferation of COLO 205 cells with an IC50 value of 0.54 μM.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: Ethanol : 5 mg/mL
Ethanol:PBS (pH 7.2) (1:1) : 0.5 mg/mL
DMF : 2.5 mg/mL
DMSO : 1.5 mg/mL
关键字: CAY10561 | CAY 10561 | CAY-10561
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