Product Introduction
Bioactivity


英文名: DMU-212

描述: DMU-212 是具有口服活性的白藜芦醇的甲基化衍生物，表现出抗分裂、抗增殖、抗氧化和促进细胞凋亡的活性。它通过诱导凋亡和激活ERK1/2蛋白阻止有丝分裂。

体外活性: DMU-212在亚微摩尔或微摩尔浓度下（0.3125-40 μM）抑制了人类黑色素瘤细胞的增殖，对于A375、Bro、MeWo和M5人类黑色素瘤细胞，其半抑制浓度（IC50）分别为0.5 μM、0.5 μM、1.25 μM和1.25 μM。[2]。

体内活性: 在SCID雌性老鼠中，DMU-212（50 mg/kg；i.g.）抑制了肿瘤生长并降低了肿瘤负担[2]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 20 mg/mL (66.59 mM)


关键字: DMU212 | Inhibitor | Apoptosis | antimitotic | Resveratrol | antioxidant | DMU 212 | ERK | inhibit | Extracellular signal regulated kinases | DMU-212 | anticancer

相关产品: JNJ-7706621 | Silybin B | Fenoprofen calcium hydrate | COTI-2 | Sodium salicylate | 2-Hydroxychalcone | Sesamol | Pinobanksin 3-(2-methyl)butyrate | Sandalore | Iberdomide

相关库: Antioxidant Compound Library | Anti-Prostate Cancer Compound Library | Anti-Liver Cancer Compound Library | Anti-Cancer Compound Library | Anti-Ovarian Cancer Compound Library | Kinase Inhibitor Library | Anti-Obesity Compound Library | Anti-Colorectal Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Bioactive Compound Library