Product Introduction
Bioactivity


英文名: 9(Z),11(E),13(E)-Octadecatrienoic Acid

描述: 9(Z),11(E),13(E)-Octadecatrienoic Acid (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil. α-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats. It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, α-ESA induced apoptosis through up-regulation of GADD45, p53, and PPARγ. In DLD-1 cells supplemented with α-ESA, apoptosis was induced via lipid peroxidation with an EC50 of 20 μM. It also inhibits DNA polymerases and topoisomerases with IC50s ranging from ~5-20 μM for different isoforms of the enzymes.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : 30 mg/mL
Ethanol:PBS (pH 7.2)(1:10) : 0.5 mg/mL
DMSO : 30 mg/mL
DMF : 30 mg/mL


关键字: 9,11,13Octadecatrienoic Acid | 9(Z),11(E),13(E)Octadecatrienoic Acid | 9(Z),11(E),13(E) Octadecatrienoic Acid