Product Introduction
Bioactivity


英文名: 9-Methoxyellipticine

描述: 9-Methoxyellipticine is an alkaloid and a derivative of the DNA intercalating agent ellipticine that has been found in O. maculataand has anticancer activity.It intercalates into DNA and is an inhibitor of wild-type c-Kit and c-Kit containing the D816V activating mutation (c-KitD816V; IC50s = 0.8 and 0.6 μM, respectively).

体外活性: 9-Methoxyellipticine inhibits proliferation of Ba/F3 cells in the presence of the c-Kit ligand SCF and Ba/F3 cells expressing c-KitD816V(IC50s = 0.5 and 0.3 μM, respectively).2It also increases survival in a variety of rodent tumor models.1

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: 9-Methoxyellipticine | 9Methoxyellipticine | 9 Methoxyellipticine