Product Introduction
Bioactivity


英文名: CDK12-IN-2

描述: CDK12-IN-2 (CDK12 inhibitor 2) 是一种有效的选择性 CDK12 抑制剂，对 CDK12、CDK2、CDK7 和 CDK9 的 IC50 为 52 nM、>100 μM、>10 μM 和 16 μM。 CDK12-IN-2可用于研究CDK12的功能。

体外活性: In SK-BR-3 cells, CDK12-IN-2 inhibits the phosphorylation of the CTD Ser2 with an IC50 of 185 nM. CDK12-IN-2 exhibits a growth inhibition with an IC50 of 0.8 μM. CDK12-IN-2 inhibits CDK12 in a time dependent manner with IC50s of 0.0078 μM, 0.042 μM, 0.057 μM,and 0.059 μM, for 0h, 1h, 2h and 5h[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (75.1 mM)


相关产品: CKI-7 | THZ1 2HCl | Bisindolylmaleimide X hydrochloride | LY3405105 | TC11 | Cdc7-IN-1 | CDK7-IN-25 | AT7519 | SB1317 | MSC2530818

相关库: Anti-Breast Cancer Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Inhibitor Library | Anti-Pancreatic Cancer Compound Library | Bioactive Compound Library