Product Introduction
Bioactivity


英文名: Sivopixant

描述: Sivopixant (S-600918) 是P2X3受体选择性拮抗剂 (P2X3IC50=4.2 nM; P2X2/3IC50=1100 nM)。Sivopixant 可用于缓解疼痛的研究。

体内活性: Sivopixant (S-600918) was identified as a clinical candidate with potent and selective antagonistic activity (P2X3 IC50, 4.2 nM; P2X2/3 IC50, 1100 nM) and a strong analgesic effect in the rat partial sciatic nerve ligation model (Seltzer model) of allodynia (ED50, 0.4 mg/kg).

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 55 mg/mL (108.28 mM)


关键字: ligation | analgesic | S 600918 | P2XRs | inhibit | pain | P2X Receptor | Inhibitor | sciatic | S600918 | nerve | selective

相关产品: A 438079 | P2X3-IN-1 | Gefapixant | P2X3 antagonist 38 | NF023 hexasodium | A 839977 | Indophagolin | Bullatine A | Opiranserin | 5-BDBD

相关库: Drug Repurposing Compound Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Clinical Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Inhibitor Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Active Compound Library