CDK6/9-IN-1 T40047
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Product IntroductionBioactivity英文名: CDK6/9-IN-1描述: CDK6/9-IN-1 (compound 66) is a potent dual inhibitor of CDK 6 and CDK
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Product Introduction
Bioactivity
英文名: CDK6/9-IN-1
描述: CDK6/9-IN-1 (compound 66) is a potent dual inhibitor of CDK 6 and CDK 9 that can be administered orally. It exhibits inhibitory activity with IC 50 values of 40.5 nM and 39.5 nM against CDK6 and CDK9, respectively.
体外活性: CDK6/9-IN-1 (compound 66, 4 or 8 μM in MDA-MB-231 cells) treatment induces G0/G1 cell cycle arrest (71.85% and 77.51%, respectively), when compared with the control (57.65%)[1].
体内活性: CDK6/9-IN-1 (compound 66) significantly inhibits tumor growth in an xenograft mouse model with no obvious toxicity, indicating the promising therapeutic potential of CDK6/9 dual inhibitors for cancer treatment[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: CDK-6/9-IN-1 | CDK6/9 IN 1 | CDK6/9IN1
Bioactivity
英文名: CDK6/9-IN-1
描述: CDK6/9-IN-1 (compound 66) is a potent dual inhibitor of CDK 6 and CDK 9 that can be administered orally. It exhibits inhibitory activity with IC 50 values of 40.5 nM and 39.5 nM against CDK6 and CDK9, respectively.
体外活性: CDK6/9-IN-1 (compound 66, 4 or 8 μM in MDA-MB-231 cells) treatment induces G0/G1 cell cycle arrest (71.85% and 77.51%, respectively), when compared with the control (57.65%)[1].
体内活性: CDK6/9-IN-1 (compound 66) significantly inhibits tumor growth in an xenograft mouse model with no obvious toxicity, indicating the promising therapeutic potential of CDK6/9 dual inhibitors for cancer treatment[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: CDK-6/9-IN-1 | CDK6/9 IN 1 | CDK6/9IN1
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