Product Introduction
Bioactivity


英文名: CAY10580

描述: CAY10580 is a potent and selective prostaglandin EP 4 receptor agonist ( K i =35 nM).

体外活性: CAY10580 (10-10000 nM; 40 min) significantly increases apical membrane abundance of AQP2 in MDCK cells at 100 to 10000 nM[2].

体内活性: CAY10580 (200 μg/kg body weight; i.p; daily for three weeks) effectively prevents diet-induced hypercholesterolemia, enhances endogenous bile acid synthesis and their fecal excretion[3]. Animal Model: Six-week old male EP4 +/+ mice (Treating high fat diet-challenged mice)[3]Dosage: 200 μg/kg body weight Administration: Intraperitoneal injection; daily for remaining three weeks Result: High fat diet fed mice exhibited lower total cholesterol levels compared to the vehicle group by 28.5%. Total cholesterol levels decreased from 137.4 to 98.2 mg/dl, restoring plasma cholesterol back to near-normal values.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: CAY-10580 | CAY 10580