Product Introduction
Bioactivity


英文名: Sterculic acid

描述: Sterculic acid 是一种硬脂酰辅酶 A 去饱和酶 1 (SCD1) 抑制剂。Sterculic acid 剂量依赖性抑制 delta-9 去饱和酶 (Δ9D) 活性，IC50值为 0.9 μM。

体外活性: Sterculic acid (SA) is a cyclopropene fatty acid originally found in the seeds of the plant Sterculia foetida and has variety of biological activities [2]. Sterculic acid is able to reduce adrenomedullin expression (AP, RP, APS, IML, in preparation) [2]. Sterculic acid is also able to mediate anti-inflammatory and protective effects [2]. Sterculic acid has a potent luteolytic effect in ovines by inhibition in the synthesis of progesterone, which causes luteal regression [2].

体内活性: Sterculic acid has been proposed as a potential tool for the treatment of metabolic syndrome (MS) due to it inhibits the activity of the stearoyl-CoA desaturase-1 (SCD1) in vivo [3].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Sterculic acid