Product Introduction
Bioactivity


英文名: SJ6986

描述: SJ6986 是有效的、选择性的、具有口服活性的GSPT1/2降解剂，对GSPT1 的DC50值为2.1 nM (Dmax99%)。

体外活性: SJ6986 shows EC 50 values of 1.5 nM, 0.4 nM, 726 nM, 336 nM and 3583 nM in MV4-11, MHH-CALL-4, MB002, MB004 and HD-MB03 cell lines, respectively [1]. Cell Proliferation Assay [1] Cell Line: MV4-11 cells. Concentration: 0-100 μM. Incubation Time: 3 days. Result: Exhibited EC 50 of 1.5 nM. Western Blot Analysis [1] Cell Line: MV4-11 cells. Concentration: 0-10 μM. Incubation Time: 4 and 24 h. Result: Dose- and time-dependently decreased the protein levels of GSPT1.

体内活性: SJ6986在CD1小鼠中，经静脉注射3 mg/kg展现出3.44小时的半衰期（t 1/2），通过口服给药10 mg/kg达到最大浓度时间（t max）为0.25小时，口服生物利用度为84%（%F=84）[1]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 55 mg/mL (110.57 mM)


关键字: SJ6986 | SJ 6986 | SJ-6986

相关库: Bioactive Compounds Library Max | Bioactive Compound Library