化合物 T5499 T5499
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Product IntroductionBioactivity英文名: gardiquimod TFA salt描述: Gardiquimod diTFA，咪唑啉类似物TLR7/8激动剂，可特异性抑制巨噬细胞和活化外周血单个核细胞(PBMCs
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Product Introduction
Bioactivity
英文名: gardiquimod TFA salt
描述: Gardiquimod diTFA，咪唑啉类似物TLR7/8激动剂，可特异性抑制巨噬细胞和活化外周血单个核细胞(PBMCs)的HIV-1感染。在浓度低于10 μM时，该化合物特异性激活TLR7。
体外活性: Gardiquimod diTFA (6-60 μM ) significantly inhibits HIV-1 reverse transcriptase to synthesis of cDNA [1].
体内活性: Dendritic cells (DCs) in combination with Gardiquimod (1 mg/kg per mouse; i.p.; daily for 7 days) enhances the anti-tumor effects of NK cells [2]. Animal Model: Male athymic nude mice (Balb-nu/nu, 5 weeks old) (bearing human HepG2 liver carcinoma xenografts) [2] Dosage: 1 mg/kg per mouse Administration: i.p.; daily for 7 days Result: Significantly suppressed the growth of human HepG2 liver carcinoma xenografts.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: gardiquimod TFA salt | gardiquimod TFA
Bioactivity
英文名: gardiquimod TFA salt
描述: Gardiquimod diTFA，咪唑啉类似物TLR7/8激动剂，可特异性抑制巨噬细胞和活化外周血单个核细胞(PBMCs)的HIV-1感染。在浓度低于10 μM时，该化合物特异性激活TLR7。
体外活性: Gardiquimod diTFA (6-60 μM ) significantly inhibits HIV-1 reverse transcriptase to synthesis of cDNA [1].
体内活性: Dendritic cells (DCs) in combination with Gardiquimod (1 mg/kg per mouse; i.p.; daily for 7 days) enhances the anti-tumor effects of NK cells [2]. Animal Model: Male athymic nude mice (Balb-nu/nu, 5 weeks old) (bearing human HepG2 liver carcinoma xenografts) [2] Dosage: 1 mg/kg per mouse Administration: i.p.; daily for 7 days Result: Significantly suppressed the growth of human HepG2 liver carcinoma xenografts.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: gardiquimod TFA salt | gardiquimod TFA
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