化合物L-765314 T5511
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Product IntroductionBioactivity英文名: L-765314描述: L-765314 是一种 α1b 肾上腺素能受体的选择性拮抗剂，其在大鼠和人体中的Ki 分别为 5.4 nM 和 2.0 nM。体内活性: L-7
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Product Introduction
Bioactivity
英文名: L-765314
描述: L-765314 是一种 α1b 肾上腺素能受体的选择性拮抗剂，其在大鼠和人体中的Ki 分别为 5.4 nM 和 2.0 nM。
体内活性: L-765314 shows weak potency for inhibiting the pressor response to either phenylephrine or A-61603 (AD25>3 mg/kg for each).?On the basis of the inhibition of pressor responses to the R1a subtype selective agonist A-61603, L-765314 appears to be selective versus the R1a receptor up to a dose of 0.3 mg/kg.?The results of hypotensive potency in rats show that both L-765314 and terazosin tend to decrease heart rate (about 25 bpm at 1 mg/kg iv)[1]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 50 mg/mL (95.68 mM)
关键字: L 765314 | L-765314 | Adrenergic Receptor | Inhibitor | Beta Receptor | L765314 | inhibit
相关产品: Phenoxybenzamine hydrochloride | Milveterol HCl | Metaraminol tartrate | Solabegron | CGP-20712 | Salmeterol | Indanidine | Oxyfedrine L-form HCl | Isorhoifolin | Guanfacine hydrochloride
相关库: Adrenergic Receptor-Targeted Compound Library | Anti-Neurodegenerative Disease Compound Library | Neurotransmitter Receptor Compound Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | GPCR Compound Library | Inhibitor Library | Bioactive Compound Library
Bioactivity
英文名: L-765314
描述: L-765314 是一种 α1b 肾上腺素能受体的选择性拮抗剂，其在大鼠和人体中的Ki 分别为 5.4 nM 和 2.0 nM。
体内活性: L-765314 shows weak potency for inhibiting the pressor response to either phenylephrine or A-61603 (AD25>3 mg/kg for each).?On the basis of the inhibition of pressor responses to the R1a subtype selective agonist A-61603, L-765314 appears to be selective versus the R1a receptor up to a dose of 0.3 mg/kg.?The results of hypotensive potency in rats show that both L-765314 and terazosin tend to decrease heart rate (about 25 bpm at 1 mg/kg iv)[1]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 50 mg/mL (95.68 mM)
关键字: L 765314 | L-765314 | Adrenergic Receptor | Inhibitor | Beta Receptor | L765314 | inhibit
相关产品: Phenoxybenzamine hydrochloride | Milveterol HCl | Metaraminol tartrate | Solabegron | CGP-20712 | Salmeterol | Indanidine | Oxyfedrine L-form HCl | Isorhoifolin | Guanfacine hydrochloride
相关库: Adrenergic Receptor-Targeted Compound Library | Anti-Neurodegenerative Disease Compound Library | Neurotransmitter Receptor Compound Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | GPCR Compound Library | Inhibitor Library | Bioactive Compound Library
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