Product Introduction
Bioactivity


英文名: GSK8612

描述: GSK8612 是一种具有高度选择性的TBK1强效抑制剂，其 pIC50=6.8。

体外活性: In cellular assays, GSK8612 inhibited toll-like receptor (TLR)3-induced interferon regulatory factor (IRF)3 phosphorylation in Ramos cells and type I interferon (IFN) secretion in primary human mononuclear cells. In THP1 cells, GSK8612 was able to inhibit secretion of interferon-beta (IFNβ) in response to dsDNA and cGAMP, the natural ligand for STING.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : Insoluble
DMSO : 100 mg/mL (192.19 mM)


关键字: Inhibitor | GSK 8612 | IKK | I kappa B kinase | GSK8612 | GSK-8612 | inhibit | IκB kinase

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相关库: Anti-Aging Compound Library | Anti-Prostate Cancer Compound Library | HIF-1 Signaling Pathway Compound Library | Anti-Liver Cancer Compound Library | NF-κB Signaling Compound Library | Anti-Ovarian Cancer Compound Library | Inhibitor Library | Kinase Inhibitor Library | Highly Selective Inhibitor Library | Bioactive Compound Library