苦参黄素 T5S0993
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Product IntroductionBioactivity英文名: Kurarinone描述: Kurarinone 是从灌木苦参中提取的黄酮类化合物，具有抗肿瘤、雌激素和抗炎活性，对免疫反应也有很强的抑制作用。体外活性: Kurarin
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Product Introduction
Bioactivity
英文名: Kurarinone
描述: Kurarinone 是从灌木苦参中提取的黄酮类化合物，具有抗肿瘤、雌激素和抗炎活性，对免疫反应也有很强的抑制作用。
体外活性: Kurarinone, a lavandulyl flavanone, was isolated from a polyphenolic extract of the roots of Sophora flavescens using fractionation guided by estrogenic activity, which was determined by recombinant yeast and Ishikawa Var-I bioassays. METHODS AND RESULTS:Kurarinone showed weak estrogenic activity both in the yeast screen and in the Ishikawa Var-I assay with EC(50) values of 4.6 and 1.66 microM, respectively. Furthermore, Kurarinone was found to have potent cytotoxic activity (IC(50) value = 22.2 microM) against human MCF-7/6 breast cancer cells in the sulforhodamine-B assay.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 55 mg/mL (125.42 mM)
关键字: Kurarinone | inhibit | Inhibitor
相关产品: Rasagiline | Tanshinone IIB | HA14-1 | Maritoclax | BM 957 | A-385358 | Ferruginol | Hinokiflavone | BAI1 | Jolkinolide B
相关库: Polyphenolic Natural Product Library | Selected Plant-Sourced Compound Library | Human Metabolite Library | Anti-Cancer Active Compound Library | Traditional Chinese Medicine Monomer Library | Natural Product Library for HTS | Flavonoid Natural Product Library | Tibetan medicine Compound Library | Natural Product Library | Bioactive Compound Library
Bioactivity
英文名: Kurarinone
描述: Kurarinone 是从灌木苦参中提取的黄酮类化合物，具有抗肿瘤、雌激素和抗炎活性，对免疫反应也有很强的抑制作用。
体外活性: Kurarinone, a lavandulyl flavanone, was isolated from a polyphenolic extract of the roots of Sophora flavescens using fractionation guided by estrogenic activity, which was determined by recombinant yeast and Ishikawa Var-I bioassays. METHODS AND RESULTS:Kurarinone showed weak estrogenic activity both in the yeast screen and in the Ishikawa Var-I assay with EC(50) values of 4.6 and 1.66 microM, respectively. Furthermore, Kurarinone was found to have potent cytotoxic activity (IC(50) value = 22.2 microM) against human MCF-7/6 breast cancer cells in the sulforhodamine-B assay.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 55 mg/mL (125.42 mM)
关键字: Kurarinone | inhibit | Inhibitor
相关产品: Rasagiline | Tanshinone IIB | HA14-1 | Maritoclax | BM 957 | A-385358 | Ferruginol | Hinokiflavone | BAI1 | Jolkinolide B
相关库: Polyphenolic Natural Product Library | Selected Plant-Sourced Compound Library | Human Metabolite Library | Anti-Cancer Active Compound Library | Traditional Chinese Medicine Monomer Library | Natural Product Library for HTS | Flavonoid Natural Product Library | Tibetan medicine Compound Library | Natural Product Library | Bioactive Compound Library
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