Product Introduction
Bioactivity


英文名: PBRM1-BD2-IN-2

描述: PBRM1-BD2-IN-2 是一种选择性和细胞活性的 PBRM1 溴化域抑制剂。PBRM1-BD2-IN-2 对 PBRM1-BD2 具有结合亲和力和抑制活性， Kd 和 IC50 值分别为 9.3 μM 和 1.0 μM。PBRM1-BD2-IN-2 可用于癌症的研究。

体外活性: PBRM1-BD2-IN-2 (0, 0.1, 1, and 10 μM; 5 days) selectively inhibit growth of a PBRM1-dependent prostate cancer cell line. PBRM1-BD2-IN-2 has binding affinity for PBRM1-BD2, PBRM1-BD5, SMARCA2B amd SMARCA4 with Kd values of 9.3 μM, 10.1 μM, 18.4 μM and 69 μM, respectively. PBRM1-BD2-IN-2 has inhibitory activity for PBRM1-BD2 with IC50 value of 1.0 μM[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 45 mg/mL (144.63 mM)


关键字: PBRM1BD2IN2 | PBRM1-BD2-IN-2

相关产品: Inobrodib | FT001 | Piflufolastat | SGC-CBP30 | PBRM1-BD2-IN-5 | OXFBD04 | ZEN-3862 | UNC 1021 | 6-Bromo-3-methyl-1,4-dihydroquinazolin-2-one | BRM/BRG1 ATP Inhibitor-1

相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Epigenetics Compound Library | Anti-Cancer Active Compound Library | PPI Inhibitor Library | Histone Modification Compound Library | Bioactive Compound Library