Product Introduction
Bioactivity


英文名: PBRM1-BD2-IN-5

描述: PBRM1-BD2-IN-5 是一种有效的 PBRM1 Bromodomain 抑制剂，对 PBRM1-BD2 和 PBRM1-BD5 的 Kd 分别为 1.5 μM 和 3.9 μM，对 PBRM1-BD2 的 IC50 为 0.26 μM。PBRM1-BD2-IN-5 减少细胞裂解物中 PBAF 复合体全长 PBRM1 与乙酰化组蛋白肽的结合。PBRM1-BD2-IN-5 可用于抗癌研究。

体外活性: PBRM1-BD2-IN-5 (compound 16) (0-10 μM; 5 days) inhibits PBRM1-expressed LNCaP cells, and reduces the binding of full-length PBRM1 within the PBAF complex in cell lysates to acetylated histone peptides[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (183.33 mM)


关键字: PBRM1BD2IN5 | PBRM1-BD2-IN-5

相关产品: PF-CBP1 hydrochloride | Tz-Thalidomide | SMARCA-BD ligand 1 for Protac dihydrochloride | BET BD2-IN-1 | I-CBP112 | BET-IN-16 | PROTAC BRD9-binding moiety 1 | AW68 | GSK9311 hydrochloride | UNC926

相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Epigenetics Compound Library | Anti-Cancer Active Compound Library | PPI Inhibitor Library | Histone Modification Compound Library | Bioactive Compound Library