Product Introduction
Bioactivity


英文名: UNC7467

描述: UNC7467 是一种有效的IP6K 抑制剂，IP6K2、IP6K1 和 IP6K6 的IC50值分别为 4.9、8.9 和1320 nM。UNC7467 可降低肌醇焦磷酸盐的水平，而不会显着干扰其他肌醇磷酸盐的水平。UNC7467 可用于肥胖研究。

体外活性: UNC7467 (2.5 μM; 3小时; HCT116细胞) 降低了肌醇焦磷酸盐水平。UNC7467使5-InsP 7水平下降了81%，而5-InsP 8水平下降了63% [1]。

体内活性: UNC7467 (5 mg/kg; i.p.; daily, for 4 weeks; diet-induced obesity mice) improved diet-induced obesity, insulin resistance, and hepatic steatosis [1]. UNC7467 (1-5 mg/kg; i.v. and i.p.; diet-induced obesity mice) exhibits low clearance (13.7 (mL/min)/kg) and large AUC last (6054 h ng/mL for intra venous (i.v.) and 2527 h ng/mL for intraperitoneal (i.p.)) in mice at 5 mg/kg dose [1]. Animal Model: Diet-induced obesity (DIO) mice [1] Dosage: 5 mg/kg Administration: Intraperitoneal injection; daily, for 4 weeks Result: Improved glycemic profiles, ameliorated hepatic steatosis, and reduced weight gain without altering food intake. Animal Model: Diet-induced obesity (DIO) mice [1] Dosage: 5 mg/kg (Pharmacokinetic Analysis) Administration: Intravenous injection and intraperitoneal injection Result: 1.19 route iv ip Dose (mg/kg) 5 5 AUC last (h*ng/mL) 6054 2527 CL (mL/min/kg) 13.7

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 3.15 mg/mL (10 mM)


关键字: UNC7467 | UNC 7467 | UNC-7467

相关库: Bioactive Compounds Library Max | Anti-Obesity Compound Library | Bioactive Compound Library