Product Introduction
Bioactivity


英文名: LCS3

描述: LCS3是一种可逆和非竞争性的谷胱甘肽二硫化物还原酶（GSR）和硫氧还蛋白还原酶1（TXNRD1）的协同抑制剂，IC50分别为3.3μM 和3.8μM。LCS3具有抗肿瘤活性，可诱导细胞凋亡，可用于研究肺腺癌（LUAD）。

体外活性: LCS3 (5 nM-10 µM ; 96 h) effectively inhibits lung cancer cell lines, while non-transformed lung cells show no signs of inhibition.[1] LCS3 (3 µM ; 3, 6, and 12 h) induces ROS and NRF2 pathway activation in sensitive lung adenocarcinoma (LUAD) cells.[1] LCS3 (3 µM ; 96 h) selectively kills lung adenocarcinoma (LUAD) cell lines, in part through the induction of apoptosis.[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 112.5 mg/mL (421.9 mM)


相关产品: Tubulin inhibitor 11 | Jaceosidin | Candesartan Cilexetil | AGN 192870 | SC144 | Erdafitinib | Deracoxib | Diethyl phthalate | Pemetrexed disodium hemipenta hydrate | Ethylene dimethanesulfonate

相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Active Compound Library | Bioactive Compound Library