化合物URMC099 T6057
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Product IntroductionBioactivity英文名: URMC-099描述: URMC-099 是一种具有优异的血脑屏障穿透性的，可口服的混合谱系激酶 3 抑制剂，IC50为14 nM。激酶实验: HDAC IC50 Pro
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Product Introduction
Bioactivity
英文名: URMC-099
描述: URMC-099 是一种具有优异的血脑屏障穿透性的，可口服的混合谱系激酶 3 抑制剂，IC50为14 nM。
激酶实验: HDAC IC50 Profiling: The in vitro inhibitory activity of compounds against seven human HDAC isoforms (1, 2, 4 C2A, 5 C2A, 6, 8, and 11) are performed with a fluorescent based assay according to the company's standard operating procedure. The IC50 values are determined using 10 different concentrations with 3-fold serial dilution starting at 10 μM. TSA and vorinostat are used as reference compounds.
体外活性: URMC-099（10 mg/kg, i.p. ）可减少体内炎性细胞因子产生,保护神经元结构,并改变小胶质细胞对HIV-1 Tat暴露下的形态和超微响应.URMC-099在小鼠体内,表现出良好的药代动力学性能和改善的CNS渗透性.URMC099明显减少野生型小鼠体内中性粒细胞通过fMLP进入腹膜.
体内活性: URMC-099可降低体外实验中fMLP诱导的野生型嗜中性粒细胞的趋药性。URMC-099还对小胶质细胞中脂多糖诱导的TNFα释放,以及人单核细胞中HIV-1 Tat诱导的细胞因子释放有抑制作用。 URMC-099防止培养的神经轴突被小胶质细胞破坏和吞噬。
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: H2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : 6 mg/mL (14.2 mM)
DMSO : 75 mg/mL (177.9 mM)
关键字: inhibit | MLKs | Autophagy | URMC099 | URMC 099 | Inhibitor | Mixed Lineage Kinase | URMC-099
相关产品: Thiazovivin | Fasudil hydrochloride | Chroman 1 | CAY10746 | GSK-25 | ROCK-IN-2 | Tofacitinib | Hydroxyfasudil Hydrochloride | Verosudil | Cucurbitacin A
相关库: Anti-Neurodegenerative Disease Compound Library | Glycometabolism Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | Apoptosis Compound Library | DNA Damage & Repair Compound Library | TGF-beta/Smad Compound Library
Bioactivity
英文名: URMC-099
描述: URMC-099 是一种具有优异的血脑屏障穿透性的，可口服的混合谱系激酶 3 抑制剂，IC50为14 nM。
激酶实验: HDAC IC50 Profiling: The in vitro inhibitory activity of compounds against seven human HDAC isoforms (1, 2, 4 C2A, 5 C2A, 6, 8, and 11) are performed with a fluorescent based assay according to the company's standard operating procedure. The IC50 values are determined using 10 different concentrations with 3-fold serial dilution starting at 10 μM. TSA and vorinostat are used as reference compounds.
体外活性: URMC-099（10 mg/kg, i.p. ）可减少体内炎性细胞因子产生,保护神经元结构,并改变小胶质细胞对HIV-1 Tat暴露下的形态和超微响应.URMC-099在小鼠体内,表现出良好的药代动力学性能和改善的CNS渗透性.URMC099明显减少野生型小鼠体内中性粒细胞通过fMLP进入腹膜.
体内活性: URMC-099可降低体外实验中fMLP诱导的野生型嗜中性粒细胞的趋药性。URMC-099还对小胶质细胞中脂多糖诱导的TNFα释放,以及人单核细胞中HIV-1 Tat诱导的细胞因子释放有抑制作用。 URMC-099防止培养的神经轴突被小胶质细胞破坏和吞噬。
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: H2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : 6 mg/mL (14.2 mM)
DMSO : 75 mg/mL (177.9 mM)
关键字: inhibit | MLKs | Autophagy | URMC099 | URMC 099 | Inhibitor | Mixed Lineage Kinase | URMC-099
相关产品: Thiazovivin | Fasudil hydrochloride | Chroman 1 | CAY10746 | GSK-25 | ROCK-IN-2 | Tofacitinib | Hydroxyfasudil Hydrochloride | Verosudil | Cucurbitacin A
相关库: Anti-Neurodegenerative Disease Compound Library | Glycometabolism Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | Apoptosis Compound Library | DNA Damage & Repair Compound Library | TGF-beta/Smad Compound Library
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