化合物 HER2-IN-11 T60896
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Product IntroductionBioactivity英文名: HER2-IN-11描述: HER2-IN-11 是能够诱导细胞凋亡的补骨脂素衍生物。HER2-IN-11 显示出光激活细胞毒性，并且具有抗乳腺癌活性。体外活性: HER
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Product Introduction
Bioactivity
英文名: HER2-IN-11
描述: HER2-IN-11 是能够诱导细胞凋亡的补骨脂素衍生物。HER2-IN-11 显示出光激活细胞毒性，并且具有抗乳腺癌活性。
体外活性: HER2-IN-11 (50 μM) has phototoxicity against SK-BR-3 cells with the IC 50 of 2.71 μM [1]. HER2-IN-11 (1-50 μM; 48 h) changes the morphology of the SK-BR-3 cells under UVA irradiation and increases the apoptotic index [1]. Apoptosis Analysis [1] Cell Line: SK-BR-3 cells Concentration: 1, 2.5, 5, 10, 20 and 50 μM Incubation Time: 48 hours Result: Broken down cells into apoptotic bodies at higher concentrations (10, 20, and 50 μM) and cell shrinkage, plasma membrane blebbing at lower concentrations (1, 2.5, and 5 μM).
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bioactivity
英文名: HER2-IN-11
描述: HER2-IN-11 是能够诱导细胞凋亡的补骨脂素衍生物。HER2-IN-11 显示出光激活细胞毒性，并且具有抗乳腺癌活性。
体外活性: HER2-IN-11 (50 μM) has phototoxicity against SK-BR-3 cells with the IC 50 of 2.71 μM [1]. HER2-IN-11 (1-50 μM; 48 h) changes the morphology of the SK-BR-3 cells under UVA irradiation and increases the apoptotic index [1]. Apoptosis Analysis [1] Cell Line: SK-BR-3 cells Concentration: 1, 2.5, 5, 10, 20 and 50 μM Incubation Time: 48 hours Result: Broken down cells into apoptotic bodies at higher concentrations (10, 20, and 50 μM) and cell shrinkage, plasma membrane blebbing at lower concentrations (1, 2.5, and 5 μM).
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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