化合物 WHI-P180 hydrochloride T61007
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Product IntroductionBioactivity英文名: WHI-P180 hydrochloride描述: WHI-P180 (Janex 3) 抑制RET, KDR 和EGFR 的IC50值分别为5 nM，66 nM 和4
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Product Introduction
Bioactivity
英文名: WHI-P180 hydrochloride
描述: WHI-P180 (Janex 3) 抑制RET, KDR 和EGFR 的IC50值分别为5 nM，66 nM 和4 μM。WHI-P180 是一种多种激酶抑制剂。
体内活性: WHI-P180 is also an active inhibitor of IgE-mediated mast cell responses. The elimination half-life of WHI-P180 in CD-1 mice (BALB/c mice) following i.v., i.p., or p.o. administration is less than 10 min. Systemic clearance of WHI-P180 is 6742 mL/h/kg in CD-I mice and 8188 mL/h/kg in BALB/c mice. Notably, WHI-P180, when administered in two consecutive nontoxic i.p. bolus doses of 25 mg/kg, inhibits IgE/antigen-induced vascular hyperpermeability in a well-characterized murine model of passive cutaneous anaphylaxis [3].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bioactivity
英文名: WHI-P180 hydrochloride
描述: WHI-P180 (Janex 3) 抑制RET, KDR 和EGFR 的IC50值分别为5 nM，66 nM 和4 μM。WHI-P180 是一种多种激酶抑制剂。
体内活性: WHI-P180 is also an active inhibitor of IgE-mediated mast cell responses. The elimination half-life of WHI-P180 in CD-1 mice (BALB/c mice) following i.v., i.p., or p.o. administration is less than 10 min. Systemic clearance of WHI-P180 is 6742 mL/h/kg in CD-I mice and 8188 mL/h/kg in BALB/c mice. Notably, WHI-P180, when administered in two consecutive nontoxic i.p. bolus doses of 25 mg/kg, inhibits IgE/antigen-induced vascular hyperpermeability in a well-characterized murine model of passive cutaneous anaphylaxis [3].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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