化合物 ARN1468 T61256
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Product IntroductionBioactivity英文名: ARN1468描述: ARN1468 (compound 5) is a highly effective orally active inhibitor of serp
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Product Introduction
Bioactivity
英文名: ARN1468
描述: ARN1468 (compound 5) is a highly effective orally active inhibitor of serpins. Inhibition of serpins activity by ARN1468 enables release of proteases, thereby reducing prion accumulation. ARN1468 demonstrates pronounced anti-prion effects in ScGT1 RML, ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, with EC 50 values of 8.64, 19.3, 11.2, and 6.27 μM [1].
体内活性: ARN1468 (compound 5) (3 mg/kg, IV; 10 mg/kg, PO; once) reveals low brain concentrations and high plasma clearance in male C57BL/6 mice [1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bioactivity
英文名: ARN1468
描述: ARN1468 (compound 5) is a highly effective orally active inhibitor of serpins. Inhibition of serpins activity by ARN1468 enables release of proteases, thereby reducing prion accumulation. ARN1468 demonstrates pronounced anti-prion effects in ScGT1 RML, ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, with EC 50 values of 8.64, 19.3, 11.2, and 6.27 μM [1].
体内活性: ARN1468 (compound 5) (3 mg/kg, IV; 10 mg/kg, PO; once) reveals low brain concentrations and high plasma clearance in male C57BL/6 mice [1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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