Product Introduction
Bioactivity


英文名: LY3372689

描述: LY3372689 (Formulaic Ia) 是一种具有口服活性的O-GlcNAcase (OGA)酶抑制剂,可用于包括阿尔茨海默病在内的 tau 蛋白类疾病。

体内活性: 在大鼠研究中，LY3372689经单次口服后表现出对OGA EO的剂量依赖性变化，最高EO超过90%。观察到与血浆浓度依赖的大脑OGA EO增加，24小时后，最高剂量LY3372689治疗组的EO超过90%。[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 225.0 mg/mL (586.8 mM)


关键字: LY3372689 | LY 3372689 | LY-3372689

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