3-(4-溴苯基)-3-(三氟甲基)-3H-双吖丙啶，952143-02-1，≥95%

中文名：3-(4-溴苯基)-3-(三氟甲基)-3H-双吖丙啶

英文名：3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine

纯度：≥95%

货号：B487384

Cas号：952143-02-1

存储温度：2-8°C储存,避光,充氩

产品介绍：

Description

3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine is a Suzuki-Miyaura (S−M)-compatible building block tailored for the design of photoaffinity probes (PAPs). Photoaffinity labeling (PAL) is of growing interest in chemical biology and drug discovery research for use in protein profiling; covalent inhibitors; protein-protein interactions and complexes; and target engagement, identification, or validation studies. Diazirines are desirable photoactivable groups forchemical probes; however, their installation is not always straightforward. In response, diazirine-tolerant S-M coupling conditions were developed by Ichiishi, et al, using 3-(4-bromophenyl)-3-(trifluoromethyl)-3H-diazirine and shown to be efficient and scalable with minimal perturbation of the diazirine.

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