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Product IntroductionBioactivity英文名: Mimosine描述: Mimosine (Leucenol) 是一种酪氨酸类似物，具有抗癌和抗炎等活性。它可通过其强大的铁结合活性作为抗氧化剂，是一种 Fe(III)
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Product Introduction
Bioactivity
英文名: Mimosine
描述: Mimosine (Leucenol) 是一种酪氨酸类似物，具有抗癌和抗炎等活性。它可通过其强大的铁结合活性作为抗氧化剂，是一种 Fe(III) 螯合剂。它作用于人类白血病细胞，通过金属离子螯合、线粒体激活和诱导活性氧产生来诱导细胞凋亡。
细胞实验: Cell proliferation in response to L-mimosine is measured using a [3H]thymidine incorporation assay. In this assay, 1 × 104 cells are cultured in each well of a 12-well plate in RPMI-1640 medium with 10% FCS and different concentrations (0–800 μM) of L-mimosine. After the required incubation periods (24 and 48 h), 0.5 μCi/ml of [3H]thymidine is added to each well of the 12-well plate. The cells are then incubated at 37°C in a humidified 5% CO2 atmosphere for 4 h. Cells are then washed twice with cold phosphate-buffered saline (PBS) and then with cold 5% trichloroacetic acid. Cells are lysed by adding 0.5 ml of 0.5 N NaOH. Then 400 μl of the solubilized cell solution are mixed with 4 ml of scintillation cocktail and counted in a liquid scintillation analyzer . Each sample was tested in quadruplicate.(Only for Reference)
体外活性: L-Mimosine 在PC-3细胞中阻断细胞周期的G1期，在LNCaP细胞中阻断S期，因此抑制了细胞增殖。[1] 作为脯氨酸羟化酶(PHD)抑制剂的L-Mimosine，可以刺激VEGF的产生，并在源自牙髓的细胞中增加它们的促血管生成能力。[2]
体内活性: L-mimosine (50 mg/kg i.p.) substantially upregulates HIF-1alpha expression in the kidneys, and remarkably enhances the natriuretic response to renal perfusion pressure in Sprague-Dawley rats. [3]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: Ethanol : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 0.01 mg/mL (0.05 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
关键字: anti-fibrosis | Fe(III) | NSC-69188 | Anti-cancer | herbicida | inhibit | Apoptosis | iron-binding | Mimosine | NSC69188 | insecticidal | chelator | antioxidant | antiinflammation | Inhibitor | anti-influenza | anti-virus
相关库: Anti-Inflammatory Traditional Chinese Medicine Compound Library | Toxic Compound Library | Mitochondria-Targeted Compound Library | Selected Plant-Sourced Compound Library | Human Metabolite Library | Ferroptosis Compound Library | Traditional Chinese Medicine Monomer Library | Natural Product Library for HTS | RO5 Drug-like Natural Product Library | Bioactive Compound Library
Bioactivity
英文名: Mimosine
描述: Mimosine (Leucenol) 是一种酪氨酸类似物，具有抗癌和抗炎等活性。它可通过其强大的铁结合活性作为抗氧化剂，是一种 Fe(III) 螯合剂。它作用于人类白血病细胞，通过金属离子螯合、线粒体激活和诱导活性氧产生来诱导细胞凋亡。
细胞实验: Cell proliferation in response to L-mimosine is measured using a [3H]thymidine incorporation assay. In this assay, 1 × 104 cells are cultured in each well of a 12-well plate in RPMI-1640 medium with 10% FCS and different concentrations (0–800 μM) of L-mimosine. After the required incubation periods (24 and 48 h), 0.5 μCi/ml of [3H]thymidine is added to each well of the 12-well plate. The cells are then incubated at 37°C in a humidified 5% CO2 atmosphere for 4 h. Cells are then washed twice with cold phosphate-buffered saline (PBS) and then with cold 5% trichloroacetic acid. Cells are lysed by adding 0.5 ml of 0.5 N NaOH. Then 400 μl of the solubilized cell solution are mixed with 4 ml of scintillation cocktail and counted in a liquid scintillation analyzer . Each sample was tested in quadruplicate.(Only for Reference)
体外活性: L-Mimosine 在PC-3细胞中阻断细胞周期的G1期，在LNCaP细胞中阻断S期，因此抑制了细胞增殖。[1] 作为脯氨酸羟化酶(PHD)抑制剂的L-Mimosine，可以刺激VEGF的产生，并在源自牙髓的细胞中增加它们的促血管生成能力。[2]
体内活性: L-mimosine (50 mg/kg i.p.) substantially upregulates HIF-1alpha expression in the kidneys, and remarkably enhances the natriuretic response to renal perfusion pressure in Sprague-Dawley rats. [3]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: Ethanol : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 0.01 mg/mL (0.05 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
关键字: anti-fibrosis | Fe(III) | NSC-69188 | Anti-cancer | herbicida | inhibit | Apoptosis | iron-binding | Mimosine | NSC69188 | insecticidal | chelator | antioxidant | antiinflammation | Inhibitor | anti-influenza | anti-virus
相关库: Anti-Inflammatory Traditional Chinese Medicine Compound Library | Toxic Compound Library | Mitochondria-Targeted Compound Library | Selected Plant-Sourced Compound Library | Human Metabolite Library | Ferroptosis Compound Library | Traditional Chinese Medicine Monomer Library | Natural Product Library for HTS | RO5 Drug-like Natural Product Library | Bioactive Compound Library
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