Product Introduction
Bioactivity


英文名: Fumagillin

描述: Fumagillin (Amebacilin) 由烟曲霉菌中提取的一种抗菌药，有抗阿米巴活性。它通过抑制 HIV-1 viral protein R 活性来抑制 HIV‐1感染。

体外活性: Fumagillin selectively inhibits the growth of a Δmap1 strain but not a wild-type or a Δmap2 S. cerevisiae strain missing MetAP-2. [1] In budding yeast cells, as a potent inhibitor of angiogenesis, Fumagillin not only reverses the growth inhibitory activity of Vpr, but also inhibits Vpr-dependent viral gene expression upon the infection of human macrophages. [3] Though the toxicity of fumagillin has limited its use for human applications, the analogues using structure-activity relationships relating to its angiogenesis properties may be further explored in the treatment of angiogenesis-dependent diseases. [4]

体内活性: In DEN-treated rats, fumagillin (30 mg/kg, i.p.) inhibits both progression of HCC in the liver itself and systemic metastasis. [2]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (109.04 mM)


关键字: Antibiotic | inhibit | Fumagillin | NSC 9168 | Human immunodeficiency virus | Parasite | Inhibitor | HIV | NSC-9168

相关产品: Nandrolone decanoate | GPS491 | Stavudine | CA inhibitor 1 | 1-Deoxymannojirimycin hydrochloride | MS417 | Dolutegravir sodium | Dolutegravir | Rottlerin | Oxindole

相关库: Drug Repurposing Compound Library | Approved Drug Library | FDA-Approved & Pharmacopeia Drug Library | Human Metabolite Library | Inhibitor Library | Anti-Parasitic Compound Library | Highly Selective Inhibitor Library | Antiparasitic Natural Product Library | Microbial Natural Product Library | Covalent Inhibitor Library