化合物MCB613 T6886
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Product IntroductionBioactivity英文名: MCB-613描述: MCB-613 是类固醇受体共激活因子 (SRC) 小分子“刺激物” (SMS)，超刺激 SRCs 的转录活性。它促进 SRC 与其他共激活因子发生
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Product Introduction
Bioactivity
英文名: MCB-613
描述: MCB-613 是类固醇受体共激活因子 (SRC) 小分子“刺激物” (SMS)，超刺激 SRCs 的转录活性。它促进 SRC 与其他共激活因子发生相互作用，并显著诱导 ER 应激与活性氧的产生相结合。它是一种 SMS，能够过度刺激 SRC 致癌程序，靶向癌基因用作抗癌药物。
细胞实验: Cells are seeded in 96-well plates and allowed to reach 60% to 70% confluence. After indicated compound treatments, relative numbers of viable cells are measured by MTS assay using the Cell Titer 96 Aqueous One Solution Cell Proliferation Assay.(Only for Reference)
激酶实验: Luciferase assays: After various compound treatments, cells are lysed in luciferase lysis buffer and assayed for luciferase activity using the ONE-Glo luciferase assay system. All luciferase activities are normalized to protein concentration determined by Bradford assay.
体外活性: MCB-613 selectively and reversibly binds to the RID of SRC-3, and selectively kills cancer cells including MCF-7 (breast), PC-3 (prostate), H1299 (lung), and HepG2 (liver) cells, without toxicity to mouse primary hepatocytes and mouse embryonic fibroblasts (MEFs). MCB-613 also increases SRCs' interactions with other coactivators and markedly induces ER stress coupled to the generation of reactive oxygen species (ROS). [1]
体内活性: In an MCF-7 breast cancer mouse xenograft model, MCB-613 (20 mg/kg, i.p.) significantly and dramatically inhibits the growth of the tumor while causing no obvious animal toxicity and body weight less. [1]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: H2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : 56 mg/mL (184 mM)
DMSO : 56 mg/mL (184 mM)
关键字: inhibit | Inhibitor | MCB613 | MCB-613
相关产品: PD180970 | Spebrutinib | RK-24466 | SI-2 hydrochloride | AD57 | BMS-536924 | WHI-P154 | PD173074 | A-770041 | SGI-7079
相关库: HIF-1 Signaling Pathway Compound Library | Anti-Cancer Metabolism Compound Library | Angiogenesis related Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | Anti-Cancer Active Compound Library | Anti-Pancreatic Cancer Compound Library | Target-Focused Phenotypic Screening Library | Bioactive Compound Library
Bioactivity
英文名: MCB-613
描述: MCB-613 是类固醇受体共激活因子 (SRC) 小分子“刺激物” (SMS)，超刺激 SRCs 的转录活性。它促进 SRC 与其他共激活因子发生相互作用，并显著诱导 ER 应激与活性氧的产生相结合。它是一种 SMS，能够过度刺激 SRC 致癌程序，靶向癌基因用作抗癌药物。
细胞实验: Cells are seeded in 96-well plates and allowed to reach 60% to 70% confluence. After indicated compound treatments, relative numbers of viable cells are measured by MTS assay using the Cell Titer 96 Aqueous One Solution Cell Proliferation Assay.(Only for Reference)
激酶实验: Luciferase assays: After various compound treatments, cells are lysed in luciferase lysis buffer and assayed for luciferase activity using the ONE-Glo luciferase assay system. All luciferase activities are normalized to protein concentration determined by Bradford assay.
体外活性: MCB-613 selectively and reversibly binds to the RID of SRC-3, and selectively kills cancer cells including MCF-7 (breast), PC-3 (prostate), H1299 (lung), and HepG2 (liver) cells, without toxicity to mouse primary hepatocytes and mouse embryonic fibroblasts (MEFs). MCB-613 also increases SRCs' interactions with other coactivators and markedly induces ER stress coupled to the generation of reactive oxygen species (ROS). [1]
体内活性: In an MCF-7 breast cancer mouse xenograft model, MCB-613 (20 mg/kg, i.p.) significantly and dramatically inhibits the growth of the tumor while causing no obvious animal toxicity and body weight less. [1]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: H2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : 56 mg/mL (184 mM)
DMSO : 56 mg/mL (184 mM)
关键字: inhibit | Inhibitor | MCB613 | MCB-613
相关产品: PD180970 | Spebrutinib | RK-24466 | SI-2 hydrochloride | AD57 | BMS-536924 | WHI-P154 | PD173074 | A-770041 | SGI-7079
相关库: HIF-1 Signaling Pathway Compound Library | Anti-Cancer Metabolism Compound Library | Angiogenesis related Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | Anti-Cancer Active Compound Library | Anti-Pancreatic Cancer Compound Library | Target-Focused Phenotypic Screening Library | Bioactive Compound Library
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