Product Introduction
Bioactivity


英文名: U-0126

描述: U0126 is a highly selective inhibitor of both MEK1 and MEK2, a type of MAPK/ERK kinase. It was found to functionally antagonize AP-1 transcriptional activity via noncompetitive inhibition of the dual specificity kinase MEK with IC50 of 72 nM for MEK1 and 58 nM for MEK2. U0126 inhibited anchorage-independent growth of Ki-ras-transformed rat fibroblasts by simultaneously blocking both extracellular signal-regulated kinase and mammalian target of rapamycin pathways.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: U-0126 | U0126 | GPA 1734 bromide | U 0126 | GPA-1734 bromide