化合物 AZ0108 T70138
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Product IntroductionBioactivity英文名: AZ0108描述: AZ0108 is an orally bioavailable, potent PARP1,2,6 inhibitor that potently
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Product Introduction
Bioactivity
英文名: AZ0108
描述: AZ0108 is an orally bioavailable, potent PARP1,2,6 inhibitor that potently inhibits centrosome clustering and is suitable for in vivo efficacy and tolerability studies. AZ0108 has been utilized as in vitro tools and in vivo probes to investigate the biological consequences of inhibiting centrosome clustering through PARP enzymes. AZ0108 is more selective in its enzyme inhibition profile and effects on cellular pathways and phenotypes. Specifically, AZ0108 inhibits PARPs 1, 2, and 6 with approximately 100-fold selectivity against PARP3 and TNKS1. Consistent with this lack of potencytowards tankyrase, AZ0108 is not active in a DLD-1 Wnt luciferase reporter assay.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: AZ-0108 | MSD D | AZ 0108 | MSD-D | AZ0108
Bioactivity
英文名: AZ0108
描述: AZ0108 is an orally bioavailable, potent PARP1,2,6 inhibitor that potently inhibits centrosome clustering and is suitable for in vivo efficacy and tolerability studies. AZ0108 has been utilized as in vitro tools and in vivo probes to investigate the biological consequences of inhibiting centrosome clustering through PARP enzymes. AZ0108 is more selective in its enzyme inhibition profile and effects on cellular pathways and phenotypes. Specifically, AZ0108 inhibits PARPs 1, 2, and 6 with approximately 100-fold selectivity against PARP3 and TNKS1. Consistent with this lack of potencytowards tankyrase, AZ0108 is not active in a DLD-1 Wnt luciferase reporter assay.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: AZ-0108 | MSD D | AZ 0108 | MSD-D | AZ0108
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