Product IntroductionBioactivity英文名:
Ipatasertib tosylate描述: Ipatasertib, also known as GDC0068, is an orally active, potent and selective Akt inhibitor. GDC-0068 blocked Akt signaling both in cultured human cancer cell lines and in tumor xenograft models. Inhibition of Akt activity by GDC-0068 resulted in blockade of cell-cycle progression and reduced viability of cancer cell lines. Markers of Akt activation, including high-basal phospho-Akt levels, PTEN loss, and PIK3CA kinase domain mutations, correlate with sensitivity to GDC-0068. In multiple tumor xenograft models, oral administration of GDC-0068 resulted in antitumor activity ranging from tumor growth delay to regression.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字:
CCT 245737(S) |
CCT245737(S) |
Ipatasertib Tosylate