Product Introduction
Bioactivity


英文名: JH-II-127

描述: JH-II-127是一种高选择性的脑渗透性 LRRK2 抑制剂，抑制野生型 LRRK2、G2019S LRRK2和 A2016T LRRK2，IC50 值分别为6.6 nM、2.2 nM 和 47.7 nM。

体内活性: JH-II-127（0.1-0.3 μM）在体外抑制了WT LRRK2和LRRK2G2019S在910和935位点丝氨酸的磷酸化。它还在小鼠的大脑、脾脏和肾脏中抑制了Ser935的磷酸化，当给药剂量为30 mg/kg时，在体内也显示出效果。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 30 mg/mL (71.97 mM)


关键字: HEK293 | JHII127 | 3T3 cells | Inhibitor | LRRK2-G2019S | Ser935 | Leucine-rich repeat kinase 2 | LRRK2 | JH-II127 | parkinson’s disease | JH-II-127 | JH-II 127 | inhibit | JH II 127 | LRRK2-A2016T

相关产品: CZC-54252 hydrochloride | MLi-2 | PF-06454589 | GNE-9605 | IKK 16 | LRRK2-IN-1 | LRRK2-IN-10 | GNE-7915 | EB-42486 | URMC-099

相关库: Anti-Neurodegenerative Disease Compound Library | Anti-Parkinson's Disease Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Inhibitor Library | Highly Selective Inhibitor Library | Autophagy Compound Library | NO PAINS Compound Library | Bioactive Compound Library