化合物 ASC-JM-17 T71552
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Product IntroductionBioactivity英文名: ASC-JM-17描述: ASC-JM-17 is an activator of both Nrf1 and Nrf2 proteins. ASC-JM17 acts
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Product Introduction
Bioactivity
英文名: ASC-JM-17
描述: ASC-JM-17 is an activator of both Nrf1 and Nrf2 proteins. ASC-JM17 acts on Nrf1, Nrf2 and Hsf1 to increase the expression of proteasome subunits, antioxidant enzymes and molecular chaperones. ASC-JM17 ameliorates toxicity of the mutant androgen receptor (AR) responsible for SBMA in cell, fly and mouse models. Knockdown of the Drosophila Nrf1 and Nrf2 ortholog cap ‘n’ collar isoform-C, but not Hsf1, blocks the protective effect of ASC-JM17 on mutant AR-induced eye degeneration in flies.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: Phenylthiourea | PTC | PTU | ASC-JM-17 | NSC-5779 | NSC5779 | Phenylthiocarbamide
Bioactivity
英文名: ASC-JM-17
描述: ASC-JM-17 is an activator of both Nrf1 and Nrf2 proteins. ASC-JM17 acts on Nrf1, Nrf2 and Hsf1 to increase the expression of proteasome subunits, antioxidant enzymes and molecular chaperones. ASC-JM17 ameliorates toxicity of the mutant androgen receptor (AR) responsible for SBMA in cell, fly and mouse models. Knockdown of the Drosophila Nrf1 and Nrf2 ortholog cap ‘n’ collar isoform-C, but not Hsf1, blocks the protective effect of ASC-JM17 on mutant AR-induced eye degeneration in flies.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: Phenylthiourea | PTC | PTU | ASC-JM-17 | NSC-5779 | NSC5779 | Phenylthiocarbamide
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