Product IntroductionBioactivity英文名:
ARN 14494描述: ARN 14494 is a potent serine palmitoyltransferase inhibitor (SPT; IC50 = 27.3 nM). ARN 14494 inhibits synthesis of long chain ceramides and dihydroceramides in an in vitro model of Alzheimer's diease. The compound prevents the synthesis of proinflammatory cytokines and the oxidative stress-related enzymes iNOS and COX-2 in mouse primary cortical astrocytes. ARN 14494 is neuroprotective against β-amyloid 1-42 induced neurotoxicity in primary cortical neurons co-cultured with astrocytes.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字:
MK1496 |
ARN-14494 |
ARN 14494 |
ARN14494 |
MK 1496.