Product Introduction
Bioactivity


英文名: S1R agonist 2

描述: S1R agonist 2 是一种具有选择性的 S1R 激动剂，对 S2R 和 S1R 的 Ki 分别为88 nM 和 1.1 nM， 对 ROS 和 NMDA 诱导的神经毒性具有保护作用。

体外活性: S1R agonist 2 (Compound 8b; 0.1-5 μ M) Both can significantly increase the growth of Neurite induced by nerve growth factor (NGF) in a dose-dependent manner.[1] The concentration of S1R agonist 2 (24 hours) in SHSY5Y cells is 1 μ M has a significant inhibitory effect on cell damage induced by Rotenone.[1] S1R agonist 2 (0.1-5 μ M; 24 hours) Neuroprotective effect on NMDA stimulation in SHSY5Y cells.[1] S1R agonist 2 (0-10 μ M; 24-72 hours) has no cytotoxicity to A549, LoVo, and Panc-1 cells.[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (161.58 mM)


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相关库: Anti-Neurodegenerative Disease Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | GPCR Compound Library | Bioactive Compound Library