Product Introduction
Bioactivity


英文名: TSPO ligand-1

描述: TSPO ligand-1 对外周和中枢苯二氮卓受体有亲和力。TSPO ligand-1 是一种线粒体外膜跨膜结构域上与 AUTAC4 结合的蛋白，可诱导线粒体自噬 (autophagy) 促进胞内线粒体更新。TSPO ligand-1 参与胆固醇在胞内的转运，可作为脑损伤和神经变性的生物标志物。

体外活性: In the context of selective activation of neurons in male C57Bl6/N mice, the TSPO ligand-1 gene is induced to increase expression. Additionally, under both physiological and psychopharmacological conditions, neuronal activation leads to increased TSPO levels in adult mice[2].As the sole marker of glial cell activity in Alzheimer’s disease, TSPO ligand-1 can track the formation of different neural cells[4].In the MA-10 Leydig cell line, TSPO ligand-1 can regulate mitochondrial fatty acid oxidation (FAO) and thus affects mitochondrial energy homeostasis[3].

存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (176.24 mM)


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相关库: Autophagy Compound Library