Product Introduction
Bioactivity


英文名: Verucerfont

描述: Verucerfont (NBI77860) 是促肾上腺皮质激素释放因子受体 1 (CRF1) 拮抗剂，作用于 CRF1(IC50:6.1 nM)，CRF2 (IC50>1000 nM)和 CRF-BP (IC50>1000 nM)。

体内活性: Verucerfont 显著抑制了应对地塞米松-CRF测试的HPA轴反应，但对酒精渴望无影响。同时，verucerfont 显著减弱了右侧杏仁体对负面情绪刺激的反应，但在一些大脑区域，包括左侧岛叶[1]，对酒精相关刺激的反应却增加了。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 86.7 mg/mL (213.29 mM)


关键字: Verucerfont | Corticotropin-releasing Factor Receptor | Inhibitor | NBI-77860 | GSK 561679 | GSK-561679 | CRFR | NBI 77860 | inhibit

相关产品: K 41498 aceate | CRF (6-33) acetate(120066-38-8 free base) | CP 376395 | Urotensin I acetate (83930-33-0 Free base) | Corticotropin-releasing factor (human) acetate | Pexacerfont | Urocortin, human | Urocortin (rat) acetate | 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1A)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(2-propyn-1-yl)-2-thiazolamine | α-helical CRF 9-41 acetate

相关库: Drug Repurposing Compound Library | ReFRAME Related Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Inhibitor Library | Anti-Cancer Clinical Compound Library | NO PAINS Compound Library | Bioactive Compound Library