Product Introduction
Bioactivity


英文名: PK11007

描述: PK11007 是一种温和的硫醇烷基化剂，具有抗癌活性。它通过两个表面暴露的半胱氨酸的选择性烷基化来稳定 p53。它通过增加活性氧水平诱导突变的 p53癌细胞死亡。

体内活性: Targeting mutant p53 with PK11007 is a potential approach for treating p53-mutated breast cancer, including the subgroup with TN disease[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 4.28 mg/mL (10 mM)


关键字: inhibit | MDM-2/p53 | Reactive Oxygen Species | Inhibitor | PK 11007 | PK-11007 | PK11007

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相关库: Anti-Breast Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Oxidation-Reduction Compound Library | Transcription Factor-Targeted Compound Library | Glutamine Metabolism Compound Library | Anti-Cancer Compound Library | NF-κB Signaling Compound Library | Anti-Cancer Active Compound Library | Autophagy Compound Library | Stem Cell Differentiation Compound Library