Product Introduction
Bioactivity


英文名: Vorsetuzumab

描述: Vorsetuzumab (Anti-Human CD70 Recombinant Antibody) 是靶向 CD70 抗体的单克隆抗体。Vorsetuzumab 具有抗癌活性，能够加强肾癌细胞巨噬相关吞噬作用，抑制 Burkitt 淋巴瘤。

体外活性: In vitro, vorsetuzumab (10 μg/mL; 2 h) augments macrophage-dependent phagocytosis of renal carcinoma cells[1].Vorsetuzumab (10 μg/mL; 2 h) can be developed into a bispecific anti-human CD70/KWAR23 antibody. The results show that KWAR23 moderately induced macrophage phagocytosis of four renal carcinoma cell lines (RCC4, RCC10, TK10, and Caki-1)[1].

体内活性: In SRG mice, vorsetuzumab (10 mg/kg; i.p.; every other day; for 12 d) inhibits the growth of Burkitt’s lymphoma cells[1].

存储条件: store at low temperaturestore at -80°C

关键字: Vorsetuzumab | SGN70 | SGN 70

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