化合物FT113 T7947
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Product IntroductionBioactivity英文名: FT113描述: FT113 是口服具有活力的脂肪酸合酶抑制剂，对全长重组人 FASN 酶的 IC50=213 nM。在 BT474 细胞中，它抑制 FASN 的特性，I
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Product Introduction
Bioactivity
英文名: FT113
描述: FT113 是口服具有活力的脂肪酸合酶抑制剂，对全长重组人 FASN 酶的 IC50=213 nM。在 BT474 细胞中，它抑制 FASN 的特性，IC50=90 nM。它具有抗增殖作用，在体内和体外实验中，都具有抗癌作用。
动物实验: Athymic nude mice bearing MV-411 cells. Dosage:5, 25, or 50 mg/kg, twice daily for 16 days
体内活性: FT113, a compound with potent biochemical and cellular activity, which translated into excellent activity in in vivo models.Caused 32 % and 50% tumor growth inhibition at 25 and 50 mg/kg, respectively in mice.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 62.5 mg/mL (152.66 mM)
关键字: Fatty Acid Synthase (FASN) | Inhibitor | FT113 | FT 113 | inhibit | FT-113
相关产品: 1-Hydroxy-2-oxopomolic acid | Pseudoprotodioscin | trans-Chalcone | Denifanstat | Cerulenin | Lycorine | Isoscoparin | FGH10019 | ACSS2-IN-2 | Fasnall HCl
相关库: Anti-Cancer Compound Library | Anti-Metabolism Disease Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Obesity Compound Library | Anti-Cancer Active Compound Library | Metabolism Compound Library | Orally Active Compound Library | NO PAINS Compound Library | Bioactive Compound Library
Bioactivity
英文名: FT113
描述: FT113 是口服具有活力的脂肪酸合酶抑制剂，对全长重组人 FASN 酶的 IC50=213 nM。在 BT474 细胞中，它抑制 FASN 的特性，IC50=90 nM。它具有抗增殖作用，在体内和体外实验中，都具有抗癌作用。
动物实验: Athymic nude mice bearing MV-411 cells. Dosage:5, 25, or 50 mg/kg, twice daily for 16 days
体内活性: FT113, a compound with potent biochemical and cellular activity, which translated into excellent activity in in vivo models.Caused 32 % and 50% tumor growth inhibition at 25 and 50 mg/kg, respectively in mice.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 62.5 mg/mL (152.66 mM)
关键字: Fatty Acid Synthase (FASN) | Inhibitor | FT113 | FT 113 | inhibit | FT-113
相关产品: 1-Hydroxy-2-oxopomolic acid | Pseudoprotodioscin | trans-Chalcone | Denifanstat | Cerulenin | Lycorine | Isoscoparin | FGH10019 | ACSS2-IN-2 | Fasnall HCl
相关库: Anti-Cancer Compound Library | Anti-Metabolism Disease Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Obesity Compound Library | Anti-Cancer Active Compound Library | Metabolism Compound Library | Orally Active Compound Library | NO PAINS Compound Library | Bioactive Compound Library
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