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Product IntroductionBioactivity英文名: Ajmalicine描述: Ajmalicine (Raubasine) 是一种有效的抗肾上腺素 (adrenolytic) 剂，优先阻断 α1-肾上腺素受体 (α1-a
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Product Introduction
Bioactivity
英文名: Ajmalicine
描述: Ajmalicine (Raubasine) 是一种有效的抗肾上腺素 (adrenolytic) 剂，优先阻断 α1-肾上腺素受体 (α1-adrenoceptor)。Ajmalicine 是一种可逆性但非竞争性尼古丁受体 (nicotine receptor) 完全抑制剂，IC50 为 72.3 μM。Ajmalicine 还可用于降压、蛇毒，具有镇静活性。
体外活性: Ajmalicine preferentially blocks α1-adrenoceptor than α2-adrenoceptor[1]. Ajmalicine inhibits contractions in a concentration-dependent manner, IC50=72.3 ± 22.5 μM[2]. Ajmalicine acts preferentially at postsynaptic sites, competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptor with a pA2 value of 6.57, blocks the inhibitory effect of clonidine with an pA2 value of 6.2[3].
体内活性: Ajmalicine blocks the pressor action of electrical stimulation and is active against sympathetic stimulation. Ajmalicine (0.5-4 mg/kg) induces a marked dose-dependent inhibition against the pressor response to noradrenaline[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 2.5 mg/mL (7.09 mM)
关键字: Ajmalicine | Δ-Yohimbine
相关产品: Olanzapine | Isoetharine mesylate salt | Bedoradrine | Ketanserin tartrate | Amiodarone hydrochloride | Mapenterol hydrochloride | Cicloprolol hydrochloride | Dopexamine hydrochloride | Taprizosin | Labetalol hydrochloride
相关库: Drug Repurposing Compound Library | Approved Drug Library | Terpene Natural Product Library | Anti-Cancer Compound Library | FDA-Approved & Pharmacopeia Drug Library | Selected Plant-Sourced Compound Library | GPCR Compound Library | Natural Product Library for HTS | Antiparasitic Natural Product Library
Bioactivity
英文名: Ajmalicine
描述: Ajmalicine (Raubasine) 是一种有效的抗肾上腺素 (adrenolytic) 剂，优先阻断 α1-肾上腺素受体 (α1-adrenoceptor)。Ajmalicine 是一种可逆性但非竞争性尼古丁受体 (nicotine receptor) 完全抑制剂，IC50 为 72.3 μM。Ajmalicine 还可用于降压、蛇毒，具有镇静活性。
体外活性: Ajmalicine preferentially blocks α1-adrenoceptor than α2-adrenoceptor[1]. Ajmalicine inhibits contractions in a concentration-dependent manner, IC50=72.3 ± 22.5 μM[2]. Ajmalicine acts preferentially at postsynaptic sites, competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptor with a pA2 value of 6.57, blocks the inhibitory effect of clonidine with an pA2 value of 6.2[3].
体内活性: Ajmalicine blocks the pressor action of electrical stimulation and is active against sympathetic stimulation. Ajmalicine (0.5-4 mg/kg) induces a marked dose-dependent inhibition against the pressor response to noradrenaline[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 2.5 mg/mL (7.09 mM)
关键字: Ajmalicine | Δ-Yohimbine
相关产品: Olanzapine | Isoetharine mesylate salt | Bedoradrine | Ketanserin tartrate | Amiodarone hydrochloride | Mapenterol hydrochloride | Cicloprolol hydrochloride | Dopexamine hydrochloride | Taprizosin | Labetalol hydrochloride
相关库: Drug Repurposing Compound Library | Approved Drug Library | Terpene Natural Product Library | Anti-Cancer Compound Library | FDA-Approved & Pharmacopeia Drug Library | Selected Plant-Sourced Compound Library | GPCR Compound Library | Natural Product Library for HTS | Antiparasitic Natural Product Library
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