Product IntroductionBioactivity英文名:
(±)-α-Bisabolol描述: (±)-α-Bisabolol (Bisabolol) 是一种从洋甘菊、念珠菌树等植物精油中提取的倍半萜烯醇,是一种天然防腐剂,具有舒缓、抗刺激、抗炎、抗氧化和抗癌活性。(±)-α-Bisabolol 通过诱导细胞周期停滞、线粒体死亡和抑制 PI3K/Akt 信号通路来发挥作用,对 A549 NSC-LC 细胞产生抗癌作用 (IC50 = 15 μM)。(±)-α-Bisabolol 能强效诱导胶质瘤细胞凋亡。
体外活性: Under resting tonus, (–)-a-bisabolol (30–300 µmol/L) relaxed duodenal strips. Contracting endothelium-intact aortic rings and urinary bladder strips, and relaxing these tissues at higher concentrations (600–1000 µmol/L). In preparations precontracted either electromechanically (by 60 mmol/L K+) or pharmacomechanically (by phenylephrine or carbachol), (–)-a-bisabolol showed only relaxing properties. [1]
体内活性: (-)-α-Bisabolol (100-200 mg/kg; p.o.; one day before and 1 h after pMCAO; once daily for the following five days; mice) significantly reduces the infarcted area and neurological deficits caused by pMCAO. (−)-α-bisabolol can exert anti-inflammatory effects by reducing astrogliosis, MPO activity, and TNF-α and iNOS production.[1] (–)-a-bisabolol attenuated the increased responses of carbachol in tracheal rings of ovalbumin-sensitized rats challenged with ovalbumin, but was without effect in the decreased responsiveness of urinary bladder strips in mice treated with ifosfamide. (–)-a-bisabolol may be an inhibitor of voltage-dependent Ca2+ channels.[2]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 90.0 mg/mL (404.7 mM)
关键字:
a-Bisabolol |
alpha-Bisabolol |
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