化合物SHR0302 T9195
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Product IntroductionBioactivity英文名: SHR0302描述: SHR0302 (ARQ252) 是一种具有口服活性的 JAK 抑制剂。它对 JAK1的结合力是 JAK2的 10 倍以上，是 JAK3的 77 倍
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Product Introduction
Bioactivity
英文名: SHR0302
描述: SHR0302 (ARQ252) 是一种具有口服活性的 JAK 抑制剂。它对 JAK1的结合力是 JAK2的 10 倍以上，是 JAK3的 77 倍，是 Tyk2的 420 倍。它抑制JAK1-STAT3磷酸化并诱导肝星状细胞凋亡，具有抗增殖和抗炎作用。
体外活性: SHR0302 (1nM-10μM) exerted an inhibitory effect on the activation, proliferation and migration of hepatic stellate cells (HSCs). SHR0302 induced the apoptosis of HSCs. The pharmacological inhibition of the JAK1/signal transducer and activator of transcription (STAT)3 pathway led to the disruption of functions essential for HSC[1].
体内活性: SHR0302 may attenuate the severity of AA rats, partially through reducing Th17 function and total B cell proportion by inhibiting JAK1-STAT3 phosphorylation[2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 30 mg/mL(72.38 mM)
关键字: Th17 | B-cell | Inhibitor | inhibit | arthritis | collagen | migration | hepatic | ARQ 252 | JAK1 | phosphorylation | anti-proliferation | Apoptosis | ARQ-252 | JAK1-STAT3 | SHR 0302 | fibrosis | SHR0302 | SHR-0302 | JAK | anti-inflammatory | Janus kinase
相关产品: CCI-007 | Vandetanib | Malachite green oxalate | Daunorubicin hydrochloride | Bax inhibitor peptide V5 acetate | PDK4-IN-1 hydrochloride | Trabectedin | TAT-BH4 (Bcl-xL) | [6]-Gingerol | BGT226 maleate
相关库: JAK-STAT Compound Library | Drug Repurposing Compound Library | Anti-Cancer Drug Library | Clinical Compound Library | Anti-Lung Cancer Compound Library | Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Inhibitor Library | Anti-Pancreatic Cancer Compound Library | NO PAINS Compound Library
Bioactivity
英文名: SHR0302
描述: SHR0302 (ARQ252) 是一种具有口服活性的 JAK 抑制剂。它对 JAK1的结合力是 JAK2的 10 倍以上，是 JAK3的 77 倍，是 Tyk2的 420 倍。它抑制JAK1-STAT3磷酸化并诱导肝星状细胞凋亡，具有抗增殖和抗炎作用。
体外活性: SHR0302 (1nM-10μM) exerted an inhibitory effect on the activation, proliferation and migration of hepatic stellate cells (HSCs). SHR0302 induced the apoptosis of HSCs. The pharmacological inhibition of the JAK1/signal transducer and activator of transcription (STAT)3 pathway led to the disruption of functions essential for HSC[1].
体内活性: SHR0302 may attenuate the severity of AA rats, partially through reducing Th17 function and total B cell proportion by inhibiting JAK1-STAT3 phosphorylation[2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 30 mg/mL(72.38 mM)
关键字: Th17 | B-cell | Inhibitor | inhibit | arthritis | collagen | migration | hepatic | ARQ 252 | JAK1 | phosphorylation | anti-proliferation | Apoptosis | ARQ-252 | JAK1-STAT3 | SHR 0302 | fibrosis | SHR0302 | SHR-0302 | JAK | anti-inflammatory | Janus kinase
相关产品: CCI-007 | Vandetanib | Malachite green oxalate | Daunorubicin hydrochloride | Bax inhibitor peptide V5 acetate | PDK4-IN-1 hydrochloride | Trabectedin | TAT-BH4 (Bcl-xL) | [6]-Gingerol | BGT226 maleate
相关库: JAK-STAT Compound Library | Drug Repurposing Compound Library | Anti-Cancer Drug Library | Clinical Compound Library | Anti-Lung Cancer Compound Library | Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Inhibitor Library | Anti-Pancreatic Cancer Compound Library | NO PAINS Compound Library
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