Product Introduction
Bioactivity


英文名: CLEFMA

描述: CLEFMA 是一种姜黄素，抑制肿瘤生长与 NF-κB 调节的抗炎和抗转移作用有关，具有抗肿瘤活性。

体外活性: CLEFMA induces autophagic death in H441 cells[1]. CLEFMA inhibits the viability of H441 and A549 cells, with IC50s of 6.4 and 8.9 μM, respectively[2]. CLEFMA induces apoptosis and reduces the DNA-binding activity of NF-κB in H441 cells in a dose-dependent manner[2].

体内活性: Daily intraperitoneal injection of 0.2-0.4 mg/kg CLEFMA for 4 weeks, CLEFMA inhibits tumor growth and FDG uptake in tumor tissue in a xenograft mouse model [2]. In addition, CLEFMA downregulates the expression of anti-apoptotic markers cIAP1, Bcl-xL, Bcl-2, and survivin, and induces the cleavage and expression of the pro-apoptotic protein BID [2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 60 mg/mL (135.66 mM)


关键字: cancer | Inhibitor | anti-metastatic | Apoptosis | antitumor | CLEFMA | curcuminoid | anti-inflammatory | inhibit

相关产品: Saikosaponin D | Capillarisin | Malachite green oxalate | Chrysotoxine | Vinpocetine | Gliotoxin | Tenuigenin | NF-κB-IN-1 | NF-κB-IN-13 | Ergolide

相关库: Antioxidant Compound Library | Transcription Factor-Targeted Compound Library | Anti-Cancer Compound Library | NF-κB Signaling Compound Library | Bioactive Compounds Library Max | Antidepressant Compound Library | Anti-Ovarian Cancer Compound Library | Inhibitor Library | Anti-Cancer Active Compound Library | Bioactive Compound Library