Product Introduction
Bioactivity


英文名: Triciferol

描述: Triciferol 作为具有结合了 VDR 激动剂和 HDAC 拮抗剂活性的多重配体发挥作用。Triciferol 直接与 VDR 结合 (IC50=87 nM)，在一些 1,25D 靶基因上作为具有 1,25D 样效力的激动剂发挥作用。Triciferol 诱导显著的微管蛋白高乙酰化，并增强组蛋白乙酰化。Triciferol 在体外癌细胞模型中也表现出有效的抗增殖和细胞毒性活性。

体外活性: Triciferol (0-10000 nM; 0-72 hours) is significantly more potent in suppressing the proliferation of estrogen receptor-negative human MDA-MB231 breast cancer cells [1]. Treatment of MCF-7 cells with Triciferol (100-1000 nM) induces ≈2.5-fold higher rates of cell death than equimolar amounts of 1,25D [1]. Cell Proliferation Assay [1] Cell Line: MDA-MB231 breast cancer cells Concentration: 0-10000 nM Incubation Time: 0-72 hours Result: Growth inhibition was statistically significantly different from that of 1,25D at concentrations of 1 nM or above.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Triciferol