化合物CU-115 T9645
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Product IntroductionBioactivity英文名: CU-115描述: CU-115 是一种有效的，选择性的 TLR8 拮抗剂。CU-115对 TLR8 和 TLR7的 IC50分别为1.04 µM 和=>50 µM。TH
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Product Introduction
Bioactivity
英文名: CU-115
描述: CU-115 是一种有效的，选择性的 TLR8 拮抗剂。CU-115对 TLR8 和 TLR7的 IC50分别为1.04 µM 和=>50 µM。THP-1 细胞中，CU-115 减少了 R-848 激活的 TNF-α 和 IL-1β 的产生。
体外活性: CU-115 (1, 5, and 20 µM) inhibits TLR9 to 10-25% inhibition. CU-115 (5-20 µM) inhibits increases in the activity of type I IFN transcriptional induced by the ssRNA nucleic acid ligands 3p-hpRNA or G3-YSD. CU-115 (5-20 µM) abolishes the TNF-α production activated by R848 (1 µg/ml) and represses the expression of IL-1β in hTHP-1 cells. CU-115 does not modulate the NF-kB inhibition induced by Pam2CSK4, Pam3CSK4, LPS, R848, Poly(I:C), and Flic in HEK-293 TLR1/2, TLR2/6, TLR3, and TLR4 cells[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 45 mg/mL (79.06 mM)
关键字: CU-115 | CU115 | CU 115
相关产品: Isofraxidin | Gardiquimod | IAXO-102 | Rabeximod | M62812 | CU-CPT17e | Pam3CSK4 TFA (112208-00-1 free base) | SM360320 | CU-CPT22 | Schaftoside
相关库: Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Bioactive Compound Library
Bioactivity
英文名: CU-115
描述: CU-115 是一种有效的，选择性的 TLR8 拮抗剂。CU-115对 TLR8 和 TLR7的 IC50分别为1.04 µM 和=>50 µM。THP-1 细胞中，CU-115 减少了 R-848 激活的 TNF-α 和 IL-1β 的产生。
体外活性: CU-115 (1, 5, and 20 µM) inhibits TLR9 to 10-25% inhibition. CU-115 (5-20 µM) inhibits increases in the activity of type I IFN transcriptional induced by the ssRNA nucleic acid ligands 3p-hpRNA or G3-YSD. CU-115 (5-20 µM) abolishes the TNF-α production activated by R848 (1 µg/ml) and represses the expression of IL-1β in hTHP-1 cells. CU-115 does not modulate the NF-kB inhibition induced by Pam2CSK4, Pam3CSK4, LPS, R848, Poly(I:C), and Flic in HEK-293 TLR1/2, TLR2/6, TLR3, and TLR4 cells[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 45 mg/mL (79.06 mM)
关键字: CU-115 | CU115 | CU 115
相关产品: Isofraxidin | Gardiquimod | IAXO-102 | Rabeximod | M62812 | CU-CPT17e | Pam3CSK4 TFA (112208-00-1 free base) | SM360320 | CU-CPT22 | Schaftoside
相关库: Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Bioactive Compound Library
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