Product Introduction
Bioactivity


英文名: Bexlosteride

描述: Bexlosteride (LY300502) 是一种苯并喹啉酮类人 I 型 5α-还原酶抑制剂。Bexlosteride 在 LNCaP 细胞培养物中显示出代谢抑制、抗增殖和抗分泌作用。Bexlosteride 可用于前列腺癌的研究。

体外活性: Bexlosteride inhibits reductive metabolism of [ 3 H-T] in a concentration-dependent manner in the LNCaP cells, with an IC 50 of 5.77 nM [1]. Bexlosteride significantly antagonizes Testosterone-induced stimulation of LNCaP cellular proliferation at concentrations greater than 10 nM, and completely blocks the mitogenic effects of Testosterone on LNCaP cells at 1000 nM[1]. Bexlosteride significantly antagonizes Testosterone -induced PSA secretion at a concentration equal to or greater than 30 nM [1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Bexlosteride