Product Introduction
Bioactivity


英文名: IC 86621

描述: IC 86621 是一种选择性和可逆的 ATP 竞争性 DNA-PK 抑制剂，IC50 为 120 nM。 IC 86621 增加 DNA 双链断裂 (DSB) 诱导的抗肿瘤活性，其 EC50 为 68 µM，用于 DNA-PK 介导的细胞 DSB 修复。

体外活性: 在CD4+CD45RO- T细胞中，IC 86621（0 nM、50 nM、100 nM）可保护类风湿性关节炎T细胞免遭凋亡[1]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (225.99 mM)


关键字: ATP | Buchwald-Hartwig amination | Inhibitor | IC 86621 | IC-86621 | DSB | IC86621 | antitumor | inhibit | Apoptosis | Fries rearrangement | DNA-dependent protein kinase | DNA-PK

相关产品: AZD-7648 | OSI-027 | Pictilisib dimethanesulfonate | PIK-93 | Samotolisib | (R)-(-)-Rolipram | NU 7026 | PI-103 | Voxtalisib | Wortmannin

相关库: Anti-Prostate Cancer Compound Library | Anti-Liver Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Neuronal Differentiation Compound Library | Anti-Lung Cancer Compound Library | Inhibitor Library | Kinase Inhibitor Library | Anti-Obesity Compound Library | Anti-Cancer Active Compound Library | Anti-Pancreatic Cancer Compound Library