化合物TJ-M2010-5 T9765
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Product IntroductionBioactivity英文名: TJ-M2010-5描述: TJ-M2010-5 是一种 MyD88 抑制剂，可与 TIR 结构域结合以干扰其同源二聚化并抑制 MyD88 信号传导。 TJ-M2010-
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Product Introduction
Bioactivity
英文名: TJ-M2010-5
描述: TJ-M2010-5 是一种 MyD88 抑制剂，可与 TIR 结构域结合以干扰其同源二聚化并抑制 MyD88 信号传导。 TJ-M2010-5 可用于心肌缺血/再灌注损伤研究。
体外活性: TJ-M2010-5（0 μM、5 μM、10 μM、20 μM 和 30 μM）可在 R848（500 ng/mL）刺激后，阻止 B 细胞增殖并诱导 B 细胞凋亡[1]。
体内活性: TJ-M2010-5 statistically significantly decreases TNF-α, IL-6, G-CSF, MIP-1β, IL-11, IL-17A, IL-22, and IL-23 serum concentrations in mice at both two and seven weeks postinduction. In a 10-week CAC mouse model, TJ-M2010-5 statistically significantly reduces AOM/DSS-induced colitis and completely prevented CAC development with less related body mass loss, results in 0% mortality of treated mice, decreases cell proliferation, and increased apoptosis in colon tissue[2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 95 mg/mL (233.68 mM)
关键字: ischemia | MIRI | Anoxia | factor | MyD88 | injury | reoxygenation | inhibit | reperfusion | differentiation | TJ-M2010-5 | Inhibitor | remodeling | myocardial | MyD88,TLR | TJ-M-2010-5 | myeloid | TJM20105 | TJ M2010 5
相关产品: EM 163 | CL075 | T6167923 | MyD88-IN-1 | TLR1 | Schaftoside
相关库: Bioactive Compounds Library Max | Inhibitor Library | Bioactive Compound Library
Bioactivity
英文名: TJ-M2010-5
描述: TJ-M2010-5 是一种 MyD88 抑制剂，可与 TIR 结构域结合以干扰其同源二聚化并抑制 MyD88 信号传导。 TJ-M2010-5 可用于心肌缺血/再灌注损伤研究。
体外活性: TJ-M2010-5（0 μM、5 μM、10 μM、20 μM 和 30 μM）可在 R848（500 ng/mL）刺激后，阻止 B 细胞增殖并诱导 B 细胞凋亡[1]。
体内活性: TJ-M2010-5 statistically significantly decreases TNF-α, IL-6, G-CSF, MIP-1β, IL-11, IL-17A, IL-22, and IL-23 serum concentrations in mice at both two and seven weeks postinduction. In a 10-week CAC mouse model, TJ-M2010-5 statistically significantly reduces AOM/DSS-induced colitis and completely prevented CAC development with less related body mass loss, results in 0% mortality of treated mice, decreases cell proliferation, and increased apoptosis in colon tissue[2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 95 mg/mL (233.68 mM)
关键字: ischemia | MIRI | Anoxia | factor | MyD88 | injury | reoxygenation | inhibit | reperfusion | differentiation | TJ-M2010-5 | Inhibitor | remodeling | myocardial | MyD88,TLR | TJ-M-2010-5 | myeloid | TJM20105 | TJ M2010 5
相关产品: EM 163 | CL075 | T6167923 | MyD88-IN-1 | TLR1 | Schaftoside
相关库: Bioactive Compounds Library Max | Inhibitor Library | Bioactive Compound Library
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